Relationship between structure and antibacterial activity of lipophilic N-acyldiamines.
نویسندگان
چکیده
We report in this work the preparation and antibacterial evaluation of a series of N-monoacylated diamines against six Gram-positive and 11 Gram-negative bacteria. The results obtained showed the existence of relationship between lipophilicity and antibacterial activity of the tested compounds. The best results were obtained against Gram-positive bacteria for compounds having a 10-12 carbons alkyl chain. Compound 4e was the most active against Microccus lentus (MIC=2 microg/mL), Staphylococcus aureus ATCC 29213 (MIC=4 microg/mL) and Enterobacter aerogenes CDC 1680 (MIC=8 microg/mL).
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ورودعنوان ژورنال:
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
دوره 64 4 شماره
صفحات -
تاریخ انتشار 2010